The hymenophoral trama of Humidicutis poilena is unusual among hygrophoroid taxa. It is formed from a distinct but narrow subregular mediostratum of inflated, short-celled hyphae surrounded by a relatively broad irregular (interwoven) lateral stratum of cylindrical to sinuous hyphae, but is not divergent (bilateral) as in Hygrophorus species. The mediostratum is similar in construction to the hymenophoral trama of Humidicutis species, while the lateral stratum is more reminiscent of the hymenophoral trama of Hygrocybe subgen. Cuphophyllus Donk (= Camarophyllus Kummer sensu auct.) species. We place H. poilena in the genus Humidicutis and not in Hygrocybe subgen. Cuphophyllus because of it non-decurrent lamellae, and the absence of clamp connections in all tissues except at the base of basidia. Moreover, the unusual, large medallion clamps at the base of basidia from which other basidia often proliferate is a typical feature of Humidicutis species (e.g., H. marginata (Pk.) Singer, H. conspicua (Horak) Horak, H. peleae Desjardin & Hemmes).

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